Selecting lead molecules of the highest possible quality is crucial for the success of any drug discovery campaign. It stands to reason that increasing the size and diversity of screening decks increases the probability of finding hits that progress to better lead molecules. Over the past couple decades, automated techniques have been widely adopted for liquid handling, plate processing, and analysis during high throughput screening (HTS). This has allowed screening of greater numbers of compounds while simultaneously reducing assay scale and burden on researchers. Similarly, in recent years DNA encoded library (DEL) technology has been rapidly growing across drug discovery. Traditionally DELs were constructed manually using a split and pool combinatorial approach, but as library sizes and the number of targets grow, the importance of automating synthesis and selection has become apparent. Here, we describe the various automation instruments used in our discovery workflow to support both the in vitro pharmacology (IVP) and DEL groups at Valo, and how these are advancing our capabilities.